Salt-Sensitive Hypertension and Inducible Nitric Oxide Synthase
نویسندگان
چکیده
منابع مشابه
Mechanisms of salt-sensitive hypertension: role of inducible nitric oxide synthase.
The goal of this study was to determine the role of inducible nitric oxide synthase (iNOS) in the arterial pressure, renal hemodynamic, renal excretory, and hormonal changes that occur in Dahl/Rapp salt-resistant (R) and salt-sensitive (S) rats during changes in Na intake. Thirty-two R and S rats, equipped with indwelling arterial and venous catheters, were subjected to low (0.87 mmol/day) or h...
متن کاملMechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase.
The goal of this study was to determine the role of renal medullary inducible nitric oxide synthase (iNOS) in the arterial pressure, renal hemodynamic, and renal excretory changes that occur in Dahl/Rapp salt-resistant (R) and salt-sensitive (S) rats during high Na intake. Forty R and S rats, equipped with indwelling arterial, venous, and renal medullary catheters, were subjected to high (8%) N...
متن کاملInhibition of Nitric Oxide Synthase 1 Induces Salt-Sensitive Hypertension in Nitric Oxide Synthase 1α Knockout and Wild-Type Mice.
We recently showed that α, β, and γ splice variants of neuronal nitric oxide synthase (NOS1) expressed in the macula densa and NOS1β accounts for most of the NO generation. We have also demonstrated that the mice with deletion of NOS1 specifically from the macula densa developed salt-sensitive hypertension. However, the global NOS1 knockout (NOS1KO) strain is neither hypertensive nor salt sensi...
متن کاملSalt-sensitive hypertension and inducible nitric oxide synthase: form-function dichotomy of a coding region mutation, Mutatis mutandis.
The earliest recorded association of dietary salt with blood pressure was reported by Huang Ti Nei Ching Su Wein (ca. 1500 B.C.), who noted that “if large amounts of salt are taken, the pulse will stiffen or harden” (page 82).1 In 1904, Ambard and Beaujard first demonstrated rigorously that dietary salt can increase blood pressure in normal volunteers.2 Throughout the 20th century, the relation...
متن کاملFunctional Inducible Nitric Oxide Synthase Gene Variants Associate With Hypertension
Increased inducible nitric oxide synthase (iNOS) activity and expression has been associated with hypertension, but less is known whether the 2 known functional polymorphic sites in the iNOS gene (g.-1026 C/A (rs2779249), g.2087 G/A (rs2297518)) affect susceptibility to hypertension. The objective of this study was to investigate the association between the genetic variants of iNOS and diagnose...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2001
ISSN: 0009-7330,1524-4571
DOI: 10.1161/res.89.4.292